Neutrophil-lymphocyte ratio in small renal masses
Wassim M Bazzi1, Sheila Z Dejbakhsh2, Melanie Bernstein1
1Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
ISRN Urology
|July 10, 2014
Summary
Preoperative neutrophil-lymphocyte ratio (NLR) was not associated with tumor pathology in patients with small renal masses (SRM). However, NLR did correlate with age, gender, race, and serum creatinine levels.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- The neutrophil-lymphocyte ratio (NLR) is an emerging biomarker for various cancers.
- Its association with clinicopathologic characteristics in small renal masses (SRM) requires further investigation.
Purpose of the Study:
- To evaluate the association between preoperative neutrophil-lymphocyte ratio (NLR) and clinicopathologic characteristics in patients with small renal masses (SRM).
Main Methods:
- Retrospective chart review of 1001 patients with SRM (≤4 cm) who underwent nephrectomy.
- Multivariable linear regression and Spearman correlation analysis were used to assess associations.
Main Results:
- Higher preoperative NLR was observed in men and Caucasians.
- NLR correlated significantly with older age and higher preoperative serum creatinine.
- No significant association was found between NLR and American Society of Anesthesiologists (ASA) score or tumor pathology (benign vs. malignant).
Conclusions:
- Preoperative NLR is not associated with tumor pathology in patients with SRM.
- Factors like age, gender, race, and serum creatinine are associated with preoperative NLR in this patient cohort.
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