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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
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Post-hemorrhagic hydrocephalus and diabetes insipidus in preterm infants

Liron Borenstein-Levin, Ilana Koren, Amir Kugelman

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |July 10, 2014
    PubMed

    Insights

    Transient central diabetes insipidus in preterm infants with hydrocephalus can resolve. This condition, linked to ventricular size reduction, is newly described in neonates.

    Area of Science:

    • Neonatal Medicine
    • Pediatric Neurology
    • Endocrinology

    Background:

    • Intraventricular hemorrhage is a known cause of diabetes insipidus in preterm infants.
    • Hydrocephalus is a common complication of intraventricular hemorrhage in neonates.

    Observation:

    • Two cases of transient central diabetes insipidus were observed in preterm neonates presenting with post-hemorrhagic hydrocephalus.
    • The diabetes insipidus was transient and resolved with reduction in ventricular size.

    Findings:

    • This study describes the association between central diabetes insipidus and hydrocephalus in neonates for the first time.
    • Transient central diabetes insipidus in this context appears reversible with decreased ventricular size, achieved through spontaneous resolution or ventriculo-peritoneal shunting.

    Implications:

    • These findings suggest that hydrocephalus-induced central diabetes insipidus in preterm neonates may be a reversible condition.
    • Monitoring and management of fluid balance are crucial in preterm neonates with hydrocephalus and signs of diabetes insipidus.
    • Further research is warranted to understand the pathophysiology and long-term outcomes.

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