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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI

J L Woodhead1, K Yang2, K L R Brouwer2

  • 1The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

CPT: Pharmacometrics & Systems Pharmacology
|July 10, 2014
PubMed
Summary

Bile salt export pump (BSEP) inhibition can cause drug-induced liver injury (DILI). Modeling reveals that inhibiting BSEP in humans increases specific bile acids in the liver, highlighting key research areas for understanding liver injury.

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