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Micro scale. Rapid and simple determination of tegafur (FT) by high pressure liquid chromatography in plasma
M Ishikawa1, M Sasaki, K Sasaki
1Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|May 1, 1989
Abstract:
A high-pressure liquid chromatographic (HPLC) method was developed for the assay of tegafur in small plasma samples of each mice using chlorouracil as the internal standard and reversed phase microparticle column. This method without any special separation and purification techniques is micro scale and simpler, more rapid and precise for the determination of tegafur in plasma of small animal than that desirable.