[Expert statement for augmentation therapy in patients with alpha-1 antitrypsin deficiency]
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Updated: Apr 27, 2026

Protein Transfection of Mouse Lung
Published on: May 15, 2013
T Köhnlein1, K Schmidt-Scherzer2, T Greulich3
1Klinikum St. Georg gGmbH Leipzig, Robert-Koch-Klinik.
Abstract:
Augmentation therapy in Alpha-1 Antitrypsin Deficiency aims to reduce the progression of lung emphysema, to reduce exacerbation frequency, and to improve quality of life. This expert statement briefly summarizes the most important treatment studies performed in patients with Alpha-1 Antitrypsin Deficiency and severe lung emphysema. Indications and contraindications for long-term intravenous augmentation therapy with human Alpha-1 Antitrypsin are derived from the available study results. Safety issues and the controversies of this topic are discussed in detail.
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