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Updated: Apr 27, 2026

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models
Published on: September 18, 2018
Prostate tumor development and androgen receptor function alterations in a new mouse model with ERG overexpression
Anjali Srivastava1, Douglas K Price1, William D Figg1
1Genitourinary Malignancies Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA.
Abstract:
Gene fusions involving ETS transcription factors (predominantly ERG and ETV1) and PTEN deletions are prevalent in the prostate cancer genome. This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. Biological mechanisms suggest increased/altered binding of the male hormone receptor in the genome. This model will be useful in pre-clinical evaluation of new drugs targeting these common prostate cancer genomic alterations.
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