The HIV-1 Env trimer in HD
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Updated: Apr 27, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
James B Munro1, Walther Mothes1
1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
Abstract:
Understanding the structure of the native HIV-1 envelope spike protein is critical for the development of vaccines and antiviral therapies. In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.
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