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Published on: November 19, 2014
Electroencephalographic abnormalities and 5-year outcome in first-episode psychosis
Rahul Manchanda1, Ross Norman2, Ashok Malla3
1Director-Prevention and Early Intervention Program for Psychoses (PEPP), London Health Sciences Centre-Victoria Hospital, London, Ontario; Professor of Psychiatry, The University of Western Ontario, London, Ontario.
Objective:
To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).
Methods:
Patients (n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.
Results:
Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.
Conclusions:
Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.
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