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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

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Biomarkers of the extracellular matrix and of collagen fragments

Georgios K Chalikias1, Dimitrios N Tziakas1

  • 1University Cardiology Department, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 11, 2014
PubMed

Insights

Cardiac extracellular matrix (ECM) changes are common in heart diseases. Circulating collagen peptides may serve as useful biomarkers for diagnosing and predicting heart failure (HF).

Area of Science:

  • Cardiology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Extracellular matrix (ECM) alterations are hallmarks of major cardiac diseases, including ischemic, pressure overload, and volume overload heart diseases, as well as cardiomyopathies.
  • Collagen types I and III are key myocardial structural proteins, and their circulating pro- or telopeptides can indicate collagen synthesis and degradation.

Purpose of the Study:

  • To review and summarize published data on cardiac ECM and its circulating biomarkers.
  • To analyze studies focusing on collagen metabolism biomarkers in heart failure (HF) patients.
  • To discuss limitations in the clinical application of these biomarkers.

Main Methods:

  • Literature review of studies on cardiac ECM and collagen metabolism biomarkers.
  • Analysis of clinical trial data concerning diagnostic and prognostic utility in heart failure.
  • Discussion of current limitations for clinical use.

Main Results:

  • Circulating collagen peptides show potential as non-invasive indicators of ECM remodeling in cardiovascular diseases.
  • These biomarkers may reflect disease activity and progression in heart failure patients.
  • Clinical trials are exploring their diagnostic and prognostic value.

Conclusions:

  • Cardiac ECM remodeling is a significant factor in heart disease.
  • Circulating collagen peptides offer a promising avenue for biomarker development in cardiology.
  • Further research is needed to overcome limitations for widespread clinical adoption.

Keywords:
BiomarkerCollagenExtracellular matrixHeart failurePeptides

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