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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Related Experiment Video

Updated: Apr 27, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Osteoclasts: more than 'bone eaters'.

Julia F Charles1, Antonios O Aliprantis1

  • 1Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Trends in Molecular Medicine
|July 11, 2014
PubMed
Summary
This summary is machine-generated.

Osteoclasts, bone-resorbing cells, also influence bone formation and interact with immune cells. This study explores their broader roles in skeletal health and disease beyond resorption.

Keywords:
PTHbone remodelingosteoblastosteoclastosteopetrosisosteoporosis

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Related Experiment Videos

Last Updated: Apr 27, 2026

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Osteoclast Derivation from Mouse Bone Marrow
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Area of Science:

  • Skeletal Biology
  • Cell Biology
  • Immunology

Background:

  • Osteoclasts are critical for bone resorption and implicated in skeletal diseases like osteoporosis.
  • The influence of osteoblasts, hematopoietic, and immune cells on osteoclasts is well-established.
  • The reciprocal effects of osteoclasts on these other cell types remain less understood.

Purpose of the Study:

  • To elucidate the functions of osteoclasts beyond bone resorption.
  • To explore osteoclast signaling in bone formation and pathology.
  • To review osteoclast interactions with the hematopoietic system and immune cells.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of osteoclast signaling pathways.
  • Examination of cellular interactions within the bone microenvironment.

Main Results:

  • Osteoclast-derived signals can influence osteoblast activity and contribute to bone pathologies.
  • Osteoclasts interact with hematopoietic stem cell niches.
  • Osteoclasts engage with adaptive immune cells, impacting immune responses.

Conclusions:

  • Osteoclasts exert multifaceted roles in the bone microenvironment, extending beyond bone resorption.
  • Understanding these broader functions is crucial for developing therapeutic strategies for skeletal and immune-related diseases.
  • Further research into osteoclast-cell interactions can provide clinical insights.