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Obsessive-compulsive behavior induced by levetiracetam.

Mayu Fujikawa1, Yuri Kishimoto1, Yosuke Kakisaka2

  • 1Department of Epileptology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Journal of Child Neurology
|July 11, 2014
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Summary
This summary is machine-generated.

Levetiracetam, an epilepsy drug, may trigger obsessive-compulsive behavior in children. This psychiatric side effect resolved after discontinuing the medication, suggesting a link.

Keywords:
glutamatelevetiracetamobsessive-compulsive behavior

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Area of Science:

  • Neurology
  • Psychiatry
  • Pharmacology

Background:

  • Levetiracetam is an effective antiepileptic drug.
  • Psychiatric adverse effects are known, but the link to obsessive-compulsive behavior is rarely reported, especially in pediatric patients.

Observation:

  • A pediatric epilepsy patient without prior psychiatric history developed obsessive-compulsive behaviors (e.g., repetitive checking) two months after starting levetiracetam.
  • The patient experienced favorable seizure control during this period.

Findings:

  • Levetiracetam was identified as the likely cause of the obsessive-compulsive behavior.
  • Discontinuation of levetiracetam led to complete resolution of the psychiatric symptoms, though seizures recurred.

Implications:

  • This case highlights that levetiracetam can induce obsessive-compulsive behavior in pediatric patients, even without a prior psychiatric background.
  • The mechanism may involve levetiracetam's modulation of the glutamate system.