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Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Delivery systems for brachytherapy.

Pilar de la Puente1, Abdel Kareem Azab1

  • 1Department of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, St. Louis, MO 63108, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 11, 2014
PubMed
Summary
This summary is machine-generated.

Brachytherapy offers precise, localized cancer treatment with reduced side effects. This review examines brachytherapy devices for various tumors, highlighting the need for further research into advanced techniques.

Keywords:
BrachytherapyBrain cancer, catheters, seed brachytherapy, and balloon brachytherapyBreast cancerHigh-dose rate (HDR)Low-dose rate (LDR)Prostate cancer

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Area of Science:

  • Oncology
  • Medical Physics
  • Radiotherapy

Background:

  • Brachytherapy involves short-distance radiation treatment using radioactive isotopes placed near tumors.
  • It offers advantages over external beam radiation (EBR) by delivering a localized dose, minimizing normal tissue irradiation.
  • Key benefits include high efficacy, reduced side effects, shorter treatment times, and cost-effectiveness.

Purpose of the Study:

  • To review brachytherapy delivery devices and their applications in treating various cancers.
  • To highlight the potential of brachytherapy for localized and small tumors.
  • To underscore the need for further research on safety, efficacy, and accuracy of new brachytherapy systems.

Main Methods:

  • Literature review of preclinical and clinical studies on brachytherapy devices.
  • Analysis of brachytherapy applications in prostate, breast, and brain cancers.
  • Examination of advancements in brachytherapy delivery devices and dose rate variations.

Main Results:

  • Brachytherapy devices have shown promising results in preclinical and clinical settings.
  • Current brachytherapy is limited to localized and relatively small tumors.
  • Newer devices enable treatment of more complex tumor sites with improved efficacy and reduced side effects.

Conclusions:

  • Brachytherapy is an effective cancer treatment modality with significant advantages for localized disease.
  • Further development of brachytherapy techniques and devices is warranted to expand its application.
  • Enhanced understanding of safety, efficacy, and accuracy is crucial for advancing brachytherapy.