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Growth of healthy term infants fed partially hydrolyzed whey-based infant formula: a randomized, blinded, controlled

Marlene W Borschel1, Yong S Choe2, Janice A Kajzer2

  • 1Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA marlene.borschel@abbott.com.

Clinical Pediatrics
|July 11, 2014
PubMed

Insights

A new partially hydrolyzed infant formula without palm olein oil (PO) showed similar infant growth but softer stools compared to a PO-containing formula. This suggests formula composition impacts infant tolerance differently.

Area of Science:

  • Pediatrics
  • Infant Nutrition
  • Gastroenterology

Background:

  • Partially hydrolyzed formulas (pHF) are widely used in infant nutrition.
  • Palm olein oil (PO) is a common ingredient in infant formulas, but its effects on tolerance are debated.
  • Developing alternative pHF formulations is of interest to the infant formula market.

Purpose of the Study:

  • To evaluate the growth and tolerance of infants fed a new whey-based, palm olein oil (PO)-free partially hydrolyzed formula (pHF) compared to a standard whey-based pHF containing PO.
  • To assess the impact of PO in pHF on infant growth parameters and stool consistency.

Main Methods:

  • A masked, randomized, parallel growth study.
  • Infants (0-8 days old) were enrolled and followed to 119 days of age.
  • Growth (weight, length, head circumference) and stool consistency were evaluated.

Main Results:

  • Mean weight gain and growth parameters (weight, length, head circumference) were similar between the PO-free pHF group and the PO-containing pHF group from 14 to 119 days.
  • Infants fed the PO-free pHF exhibited significantly softer stools than those fed the PO-containing formula, except at 119 days of age.

Conclusions:

  • While infant growth may be comparable between different partially hydrolyzed formulas in the first 4 months of life, formula composition can influence infant tolerance.
  • The absence of palm olein oil in a partially hydrolyzed formula may lead to improved stool consistency in infants.

Keywords:
hydrolysate formulainfant feedinginfant formulainfant growthweight

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