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Transport of thyroid hormone in brain
Eva K Wirth1, Ulrich Schweizer2, Josef Köhrle1
1Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin , Berlin , Germany.
Frontiers in Endocrinology
|July 11, 2014
Summary
Thyroid hormone (TH) transport into the brain is crucial for development and adult function. Key factors include serum binding proteins, cerebrospinal fluid transthyretin, and transmembrane transporters like MCT8, influencing brain TH distribution.
Area of Science:
- Neuroendocrinology
- Molecular Biology
- Physiology
Background:
- Thyroid hormone (TH) is essential for central nervous system (CNS) development and adult function.
- TH transport across barriers and within the brain regulates its availability to cells.
Purpose of the Study:
- To review key factors and structures regulating thyroid hormone uptake and distribution in the brain.
- To discuss the roles of serum binding proteins, barriers, and transporters in TH CNS regulation.
Main Methods:
- Literature review focusing on thyroid hormone transport mechanisms.
- Discussion of serum binding proteins, blood-brain barrier (BBB), blood-cerebrospinal fluid (CSF) barrier, and transmembrane transporters.
- Analysis of species differences and interference by endogenous/exogenous compounds.
Main Results:
- Serum binding proteins modulate free TH availability for cellular uptake.
- Transthyretin in CSF, secreted by the choroid plexus, influences TH distribution.
- Transmembrane transporters, such as monocarboxylate transporter 8 (Mct8), are critical for TH transport across the BBB and within the brain.
Conclusions:
- Thyroid hormone transport into and within the brain is a complex process involving multiple proteins and barriers.
- Understanding these mechanisms is vital for comprehending CNS development, function, and the impact of disruptions.
Keywords:
Mct8blood–brain-barrierdeiodinaseendocrine disruptorsflavonoidsl-type amino acid transporterorganic anion transporterstransthyretinMore Related Videos
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