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Related Experiment Videos

Predicting fractures in women by using forearm bone densitometry.

P Gärdsell1, O Johnell, B E Nilsson

  • 1Department of Orthopaedics, Malmö General Hospital, Lund University, Sweden.

Calcified Tissue International
|April 1, 1989
PubMed
Summary

Forearm bone mineral content (BMC) predicts fracture risk in postmenopausal women under 70. Lower BMC significantly increases fracture risk, especially in proximal sites, but this link weakens in older women.

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Area of Science:

  • Gerontology
  • Osteoporosis Research
  • Bone Health

Background:

  • Bone mineral content (BMC) is a key indicator of bone health.
  • Fracture risk increases with age, particularly after menopause.
  • Previous studies suggest a link between low BMC and fracture incidence.

Purpose of the Study:

  • To investigate the association between forearm bone mineral content (BMC) and subsequent fracture incidence.
  • To determine if this association differs by menopausal status and age group.

Main Methods:

  • Longitudinal study of 1,076 women with forearm BMC measured by single photon absorptiometry (SPA).
  • Fracture incidence recorded over a 10-16 year follow-up period (1975-1985).
  • Statistical analysis to correlate BMC levels with fracture types and relative risk across different age groups.

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Main Results:

  • Significantly lower BMC was observed in women who later experienced fragility fractures, specifically in the first post-menopausal decades.
  • In women aged 50-69, diminished distal forearm BMC showed a threefold, and proximal forearm BMC a sixfold, increase in relative fracture risk.
  • This association was not significant in women over 70, who exhibited high fracture rates even with higher BMC, but showed lower body weight and grip strength in the fracture group.

Conclusions:

  • Forearm BMC is a significant predictor of fragility fractures in women during the early post-menopausal years.
  • The predictive value of BMC for fractures diminishes in older age groups (over 70).
  • In older women, other factors like body weight and grip strength may play a more prominent role in fracture risk.