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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

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The Korean Medication Algorithm for Depressive Disorder: second revision.

Jeong Seok Seo¹, Hoo Rim Song², Hwang Bin Lee³

¹Department of Psychiatry, School of Medicine, Konkuk University, Chungju, Korea.

Journal of Affective Disorders

|July 11, 2014

Summary

This summary is machine-generated.

The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2012 guidelines recommend antidepressant monotherapy for most major depressive disorder (MDD) cases, but favor atypical antipsychotics for psychotic depression. Treatment duration varies by episode history.

Keywords:

Algorithm Depressive disorder Guideline Revision

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Area of Science:

Psychiatry and Clinical Psychology
Pharmacology
Evidence-Based Medicine

Background:

Major depressive disorder (MDD) treatment guidelines require regular updates to reflect evolving clinical consensus and research.
The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) provides expert-driven recommendations for MDD management.

Framework:

Revision of KMAP-DD 2006 guidelines based on expert consensus from 2006-2012 and new clinical trial data.
Expert consensus obtained via a 44-item questionnaire covering various MDD presentations, treatment phases, and special populations.

Implementation:

Antidepressant (AD) monotherapy recommended as first-line for non-psychotic MDD across age groups and specific conditions (postpartum, premenstrual dysphoric disorder).
Combination of AD and atypical antipsychotics (AAP) recommended for psychotic MDD.
Treatment duration for psychotic MDD depends on episode history; maintenance recommended for ≥3 episodes.

Implications:

KMAP-DD 2012 guidelines show continuity with 2006 but indicate a stronger preference for first-line AAP use in specific MDD subtypes.
Updated guidelines support evidence-based pharmacological strategies for diverse MDD patient profiles.