Aortic valve sclerosis is associated with lower serum adiponectin levels
Gizem Çabuk1, Umit Guray, Habibe Kafes
1Department of Cardiology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 11, 2014
Summary
Patients with aortic sclerosis have lower levels of adiponectin, an anti-inflammatory protein. This finding suggests adiponectin may play a role in the progression of degenerative aortic valve disease.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
Background:
- Aortic sclerosis, characterized by sclerotic lesions, shares similarities with atherosclerosis.
- Adiponectin, an anti-inflammatory protein, is known for its protective effects on the cardiovascular system.
Purpose of the Study:
- To quantify serum adiponectin levels in patients diagnosed with aortic sclerosis.
- To compare these levels with a control group matched for age and cardiovascular risk factors.
Main Methods:
- Serum adiponectin levels were measured using solid-phase enzyme-linked immunosorbent assay (ELISA).
- The study included 68 patients with aortic sclerosis and 40 control participants.
Main Results:
- Patients with aortic sclerosis exhibited significantly lower serum adiponectin levels compared to controls.
- Higher levels of high-sensitive C-reactive protein (hsCRP) were observed in the aortic sclerosis group.
- Adiponectin levels showed significant correlations with body mass index (BMI), white blood cell count, hsCRP, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides.
Conclusions:
- Serum adiponectin levels are significantly reduced in individuals with aortic sclerosis.
- The findings indicate a potential role for adiponectin in the pathogenesis and progression of degenerative aortic valve disease.
More Related Videos
05:47Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
3.8K
04:30Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
3.0K
Related Concept Videos
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
925
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
925
01:26Atherosclerosis III: Management
719
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
719
01:30Peripheral Artery Disease I: Introduction
655
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
655
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.1K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.1K
01:25Aortic Regurgitation III: Medical Management
583
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
583
01:30Coronary Artery Disease I: Introduction
1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K