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Improved ligand binding by antibody-aptamer pincers

Sungmuk Kang1, Sang Soo Hah

  • 1Department of Chemistry and Research Institute for Basic Sciences, Kyung Hee University , 1 Hoegi-dong Dongdaemun-gu, Seoul 131-701, South Korea.

Bioconjugate Chemistry
|July 11, 2014
PubMed
Summary

We developed antibody-aptamer pincers (AAPs) to enhance binding affinity for targets like thrombin and HER2. This novel system improves molecular targeting and shows potential for cancer drug delivery systems.

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