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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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[Rare hereditary tumours].

Péter Nagy1, Erika Lahm1, Zsuzsanna Pápai1

  • 1Onkológiai Osztály, MH Honvédkórház, Budapest, Hungary. n.peter4@gmail.com.

Magyar Onkologia
|July 11, 2014
PubMed
Summary

Hereditary tumors, accounting for 5-10% of all cancers, are linked to genetic diseases. Despite increased malignancy risk, even multiple tumors, treatment and outcomes are similar to non-hereditary cancers.

Area of Science:

  • Oncology
  • Genetics
  • Clinical Medicine

Background:

  • Hereditary tumors represent 5-10% of all neoplasms.
  • These are often part of tumor syndromes or genetic disease complications.
  • Understanding these rare conditions is crucial for patient management.

Observation:

  • Presents clinical signs, diversity, and challenges in patients with hereditary tumors.
  • Highlights increased incidence of malignancies in genetic diseases.
  • Notes the occurrence of multiple neoplasms within the same patient.

Findings:

  • Therapeutic approaches for hereditary tumors are consistent with standard cancer treatments.
  • Outcomes for hereditary tumors are comparable to those without a genetic predisposition.

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  • Genetic diseases significantly increase the risk of developing cancers.

    • Implications:

    • Emphasizes the importance of recognizing genetic predispositions for cancer.
    • Suggests that early identification and standard treatment can lead to favorable prognoses.
    • Underscores the need for further research into specific hereditary cancer syndromes.