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Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
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Stress-induced hyperalgesia.

Elaine M Jennings1, Bright N Okine1, Michelle Roche2

  • 1Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland; NCBES Centre for Pain Research and Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.

Progress in Neurobiology
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Summary
This summary is machine-generated.

Stress and anxiety significantly impact pain perception, sometimes worsening it. Understanding stress-induced hyperalgesia (SIH) through preclinical models is key to developing new pain treatments.

Keywords:
AnxietyBrainHumanPainRodentStress

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Area of Science:

  • Neuroscience
  • Pain Research
  • Psychophysiology

Background:

  • Emotion, particularly stress and anxiety, profoundly influences pain perception.
  • Stress can either reduce or intensify pain, depending on its characteristics.
  • Chronic stress may lead to maladaptive neurobiological changes, causing stress-induced hyperalgesia (SIH).

Purpose of the Study:

  • To review clinical and preclinical models of stress-induced hyperalgesia (SIH).
  • To discuss the underlying neural mechanisms, neurotransmitters, and neuromodulatory systems involved in SIH.
  • To highlight the importance of preclinical studies for understanding and treating stress-related pain syndromes.

Main Methods:

  • Review of existing clinical and preclinical research on stress and pain.
  • Analysis of neurobiological changes associated with chronic stress exposure.
  • Discussion of neural pathways and molecular mechanisms implicated in SIH.

Main Results:

  • Exposure to acute or chronic stress can alter pain responses in experimental and clinical settings.
  • Chronic stress can induce maladaptive neurobiological changes, leading to hyperalgesia.
  • SIH involves complex interactions within pain processing pathways.

Conclusions:

  • Preclinical models are crucial for elucidating the mechanisms of SIH.
  • Understanding these mechanisms aids in identifying therapeutic targets for stress-related pain.
  • Further research into neural substrates and neuromodulatory systems is essential for clinical management.