Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

22
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
22
Inflammation01:38

Inflammation

46.2K
Overview
46.2K
Inflammatory Response01:28

Inflammatory Response

12.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.4K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

15.7K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
15.7K
Inflammation: Introduction01:28

Inflammation: Introduction

46
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
46
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

45
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
45

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitoception via the Metabokine GDF15 and Human Health.

Biopsychosocial science and medicine·2026
Same author

Clinical and Demographic Determinants of Adherence to Digital Monitoring in Cirrhosis: A Prospective Cohort Analysis.

Research square·2026
Same author

Mapping the GDF15 arm of the integrated stress response in human cells and tissues.

Communications biology·2026
Same author

Association between muscle-strengthening activity participation and estimated arterial stiffness in adults: evidence from NHANES 1999-2006.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2026
Same author

Evidence for an energy conservation model of inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth.

Molecular psychiatry·2026

Related Experiment Video

Updated: Apr 27, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

19.5K

Inflamm-aging does not simply reflect increases in pro-inflammatory markers.

Vincent Morrisette-Thomas1, Alan A Cohen1, Tamàs Fülöp2

  • 1Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, CHUS-Fleurimont, 3001 12eAvenue North, Sherbrooke, QC J1H 5N4, Canada.

Mechanisms of Ageing and Development
|July 11, 2014
PubMed
Summary

Principal component analysis (PCA) reveals a new structure in inflammatory biomarkers, showing that combined pro- and anti-inflammatory markers predict aging and mortality better than single markers.

Keywords:
AgingBiomarkerChronic diseaseInflammationMultivariate

More Related Videos

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.0K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

25.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

19.5K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.0K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

25.4K

Area of Science:

  • Biodemography
  • Immunology
  • Gerontology

Background:

  • Biomarkers of inflammation are crucial for understanding aging and chronic diseases.
  • Chronic low-grade inflammation, or inflamm-aging, is linked to aging and characterized by pro-inflammatory biomarkers.
  • Single inflammatory markers can yield conflicting results due to complex interactions.

Purpose of the Study:

  • To explore the multidimensional structure of inflammatory biomarkers using principal component analysis (PCA).
  • To investigate the relationship between inflammatory marker structure, age, and health outcomes like mortality and chronic diseases.

Main Methods:

  • Applied PCA to 19 inflammatory biomarkers from the InCHIANTI study.
  • Analyzed the correlation of identified PCA axes with age.
  • Assessed the predictive power of PCA axes for mortality and chronic diseases.

Main Results:

  • PCA identified two stable axes: inflammatory activation and innate immune response.
  • The inflammatory activation axis strongly correlated with age and predicted mortality and chronic diseases.
  • Both axes were more predictive of baseline chronic diseases and mortality than individual markers.

Conclusions:

  • PCA can reveal novel biological structures within inflammatory marker relationships.
  • Key dimensions of inflammatory marker structure are significant predictors of aging, mortality, and chronic disease.
  • A multidimensional approach offers a more robust understanding of inflammation's role in health and disease.