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Related Experiment Video

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A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
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Monocyte-plasmablast crosstalk during dengue.

Angela M Green1, Eva Harris1

  • 1Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

Cell Host & Microbe
|July 11, 2014
PubMed
Summary

Dengue virus infection causes a significant increase in B cell plasmablasts. Researchers identified CD14(+)CD16(+) monocytes as key players in generating these responses during dengue infection.

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • Dengue virus infection is known to cause a significant expansion of B cell plasmablasts.
  • The precise cellular mechanisms driving this plasmablast expansion during dengue remain incompletely understood.

Purpose of the Study:

  • To investigate the role of specific monocyte subsets in the generation of B cell plasmablast responses during dengue virus infection.

Main Methods:

  • Transcriptomic analysis was performed.
  • Studies integrated human clinical samples and nonhuman primate models.
  • Coculture of primary human cells was utilized.

Main Results:

  • CD14(+)CD16(+) monocytes were identified as crucial for generating plasmablast responses.

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  • Transcriptomic data provided insights into cellular pathways involved.

    • Conclusions:

    • CD14(+)CD16(+) monocytes play a significant role in the B cell plasmablast response to dengue virus infection.
    • This finding contributes to understanding the immune response dynamics in dengue.