Related Experiment Video
Updated: Apr 27, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
[Planning disorders in men with schizophrenia and in men with localized frontal lobe lesions]
Aim:
Planning disorders have been observed in people with frontal lobe lesions for many decades. There's also growing body of evidence of frontal dysfunction in people with schizophrenia. The aim of this study is to compare the planning abilities in men with schizophrenia, men with localized frontal lobe lesions and healthy men.
Method:
A sample of 90 men participated in the study. They were divided into three groups: men with schizophrenia (n = 30), men with localized frontal lobe lesions (n = 30) and healthy men (n = 30) as a control group. Planning abilities were assessed with a clinical trial based on Tower of London task.
Results:
Significant differences in ToL measures were found between controls and men with schizophrenia (Trials solved: p < 0.01; Trials solved perfectly: p < 0.05; Execution time: p < 0.001) and between controls and men with frontal lobe lesions (Trials solved: p < 0.001; Thinking time: p < 0.05; Execution time: p < 0.001). No significant differences were found between schizophrenia and frontal lobe lesion groups.
Conclusions:
Similar deficits in planning and solving problems, which require planning, may be observed in men with schizophrenia and men with frontal lobe lesions. In both groups time spent on thinking is less effective than in healthy men. Not only quantitative, but also qualitative assessment should be carried when examining patients' performance on Tower of London task.
Related Concept Videos
Schizophrenia
Personality Disorders: Paranoid and Schizoid
Paranoid Personality Disorder
Paranoid personality disorder is...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Psychosurgery
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Panic Disorder

