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[Linear insertion of atrioventricular valves in children with and without Down's syndrome]

Ghassan Chehab, Zakhia Saliba, Bernard Gerbaka

    Le Journal Medical Libanais. the Lebanese Medical Journal
    |July 12, 2014
    PubMed

    Insights

    Linear insertion of the atrioventricular valves (LIAVV) is more common in males and children with Down

    Area of Science:

    • Cardiovascular Medicine
    • Pediatric Cardiology
    • Genetics

    Context:

    • A cohort of 6240 pediatric patients (0-16 years) with and without congenital heart disease (CHD) was analyzed.
    • Data was collected over six years (2005-2011) from the Lebanese National Registry of Pediatric and Congenital Heart Disease.
    • Patients were categorized into two groups: those with Down's syndrome (DS) and those without.

    Purpose:

    • To investigate the parameters of linear insertion of the atrioventricular valves (LIAVV).
    • To compare the incidence and characteristics of LIAVV in pediatric patients with and without Down's syndrome (DS).
    • To identify associated cardiac anomalies and sex distribution in LIAVV cases.

    Summary:

    • LIAVV was identified in 20% of pediatric patients with DS (31/155) and 0.2% without DS (14/5995), with a highly significant p-value (<0.00001).
    • A marked male predominance was observed for LIAVV, particularly in isolated cases (86% males).
    • Family history of DS was noted in some children without DS presenting with isolated LIAVV.

    Impact:

    • This study highlights the increased prevalence of LIAVV in pediatric patients with Down's syndrome.
    • Findings emphasize the importance of considering LIAVV in male pediatric patients, especially those with DS or a family history of DS.
    • The research contributes to understanding the spectrum of congenital heart disease in pediatric populations.
    Abstract

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