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Updated: Apr 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Quinoxaline, its derivatives and applications: A State of the Art review
Joana A Pereira1, Ana M Pessoa2, M Natália D S Cordeiro3
1Ciências Químicas e Biomoléculas, Centro de Investigação em Saúde e Ambiente (CISA), Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto (ESTSP-IPP), Rua Valente Perfeito 322, 4400-330 Vila Nova de Gaia, Portugal.
Abstract:
Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
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