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Hematological abnormalities associated with anticardiolipin antibodies
Haematologica
|March 1, 1989
Summary
Anticardiolipin antibodies are increasingly linked to autoimmune diseases and blood disorders. This review covers their clinical significance and role in conditions like thrombosis and thrombocytopenia.
Area of Science:
- Immunology
- Hematology
Background:
- Growing body of research on anticardiolipin antibodies (aCL) in autoimmune diseases.
- Established associations between aCL and hematologic disturbances.
Purpose of the Study:
- To review the clinical significance of detecting and measuring anticardiolipin antibodies.
- To explore the role of aCL in various blood disorders.
Main Methods:
- Literature review of recent studies.
- Synthesis of clinical and laboratory findings.
Main Results:
- Anticardiolipin antibodies are associated with recurrent thromboses.
- aCL are linked to autoimmune thrombocytopenia and positive Coombs' test.
- Lupus anticoagulant presence is often noted with aCL.
Conclusions:
- Detection and measurement of anticardiolipin antibodies are clinically significant.
- Anticardiolipin antibodies play a putative role in the pathogenesis of diverse blood disorders.