[Meta-analysis of total thyroidectomy for multinodular goiter].

Area of Science:

• Endocrinology
• Surgical Oncology
• General Surgery

Background:

• Multinodular goiter is a common thyroid condition requiring surgical intervention.
• The choice between total and subtotal thyroidectomy impacts recurrence and complication rates.

Purpose of the Study:

• To systematically compare the efficacy and safety of total thyroidectomy versus subtotal thyroidectomy for treating multinodular goiter.

Main Methods:

• A comprehensive literature search was conducted across multiple databases up to November 2013.
• Included were randomized controlled trials comparing total (or near-total) and subtotal thyroidectomy for multinodular goiter.
• Meta-analysis was performed using RevMan5.1 software on data from 7 studies involving 2,192 patients.

Main Results:

• Total thyroidectomy significantly reduced the nodule recurrence rate (OR=0.13).
• Transient hypoparathyroidism rates were higher with total thyroidectomy (OR=2.33).
• No significant differences were observed in permanent recurrent laryngeal nerve paralysis or permanent hypoparathyroidism rates between the two surgical approaches.

Conclusions:

• Total thyroidectomy is associated with a lower rate of nodule recurrence in multinodular goiter compared to subtotal thyroidectomy.
• The procedure does not increase the risk of permanent complications such as nerve paralysis or hypoparathyroidism.