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[Cross-sectional study on high-normal blood pressure and chronic kidney disease in occupational physical examination
1Department of Health Management, Third Xiangya Hospital, Central South University, Changsha 410013,China.
Insights
High-normal blood pressure increases chronic kidney disease (CKD) risk, especially in men. Hyperuricemia is an independent risk factor for CKD in this population.
Area of Science:
- Nephrology
- Cardiovascular Health
- Occupational Medicine
Background:
- Chronic kidney disease (CKD) poses a significant public health challenge.
- High-normal blood pressure is increasingly recognized as a potential risk factor for various health conditions.
- Understanding CKD prevalence in occupational settings is crucial for targeted health interventions.
Purpose of the Study:
- To examine the association between high-normal blood pressure and CKD.
- To identify risk factors for CKD in a Chinese occupational cohort.
Main Methods:
- A cross-sectional survey of 11,274 white-collar workers in Changsha.
- Classification of participants into four blood pressure groups: normal, high-normal, undiagnosed hypertension, and diagnosed hypertension.
- Logistic regression analysis to determine CKD risk factors.
Main Results:
- CKD prevalence increased with blood pressure categories: 3.31% (normal) to 17.35% (diagnosed hypertension).
- Males with high-normal blood pressure had a 1.30-fold increased CKD risk compared to optimal blood pressure.
- Hyperuricemia significantly elevated CKD risk in men with high-normal blood pressure (OR 2.25).
Conclusions:
- High-normal blood pressure is associated with a higher prevalence of CKD in occupational populations.
- Men with high-normal blood pressure face elevated CKD risk.
- Hyperuricemia is an independent risk factor for CKD in this demographic.
Objective:
To investigate the relationship between high-normal blood pressure and chronic kidney disease (CKD) in occupational physical examination population in Changsha.
Methods:
With a convenient sampling method, a cross-sectional survey of representative sample of 11 274 white collar workers was conducted in Changsha between March 2011 and May 2011 in a large comprehensive hospital. All subjects were assigned into 4 groups: a normal blood pressure group, a high-normal blood pressure group, an undiagnosed hypertension group, and a diagnosed hypertension group. Anthropometry, blood pressure, blood sample and urine sample were measured with standard instruments and methodology for all the subjects. Multiple logistic regression analysis was used to identify risk factors for CKD.
Results:
The prevalence of CKD in the normal blood pressure, high-normal blood pressure, undiagnosed hypertension, and diagnosed hypertension were 3.31%, 6.60%, 11.78%, and 17.35%, respectively. The prevalence of CKD in males was significantly higher than that in females (P<0.01). For males with high-normal blood pressure, the CKD risk was significantly greater (OR, 1.30; 95% CI:1.03 - 1.63) than those with optimal blood pressure. The logistic regression analysis showed that there was an additive effect of hyperuricemia on CKD risk in men with high-normal blood pressure compared with men with optimal blood pressure (OR, 2.25; 95% CI, 1.59 - 3.19; P<0.05).
Conclusion:
The prevalence of CKD in people with the high-normal blood pressure is 6.60% in occupational physical examination population in Changsha. CKD is a high risk for men with highnormal blood pressure and hyperuricemia is an independent risk factor.
