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Updated: Apr 27, 2026

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
A modular designed copolymer with anti-thrombotic activity and imaging capability
1School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China. mingzhao@bjmu.edu.cn sqpeng@bjmu.edu.cn.
Abstract:
Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo.
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