Comorbidity between depression and asthma via immune-inflammatory pathways: a meta-analysis
Mingdi Jiang1, Ping Qin2, Xu Yang1
1Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, China.
Journal of Affective Disorders
|July 12, 2014
Summary
Asthma and depression frequently coexist. This review found elevated inflammatory cytokines, like IL-4, IL-6, and TNF-α, in depressed individuals, suggesting inflammation links these conditions.
Area of Science:
- Immunology
- Psychiatry
- Pulmonology
Background:
- Comorbidity of asthma and depression is frequently observed.
- Allergic mechanisms may link the pathophysiology of asthma and depression.
Purpose of the Study:
- To review existing literature on the comorbidity of asthma and depression.
- To investigate potential biological links, specifically inflammatory pathways, between asthma and depression.
Main Methods:
- Systematic review and meta-analysis of epidemiological studies.
- Analysis of cytokine concentrations in depressed versus non-depressed subjects.
Main Results:
- High comorbidity rates confirmed in multiple studies.
- Significantly elevated levels of IL-1, IL-4, IL-6, and TNF-α in depressed individuals compared to controls.
- No significant differences in T cell-related cytokines (IFN-γ, IL-10) were observed.
Conclusions:
- Specific cytokine levels are implicated in the onset and remission of both asthma and depression.
- Inflammatory response pathways may represent a common mechanism underlying both conditions.
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