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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Trafficking mechanisms and regulation of TRPC channels

Lorena Brito de Souza1, Indu S Ambudkar1

  • 1Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States.

Cell Calcium
|July 12, 2014
PubMed

Insights

Transient Receptor Potential Canonical (TRPC) channels regulate cellular functions. This review details intracellular trafficking pathways and mechanisms governing TRPC1-TRPC7 channel surface expression and function.

Area of Science:

  • Molecular biology
  • Cellular physiology
  • Ion channel research

Background:

  • Transient Receptor Potential Canonical (TRPC) channels are Ca(2+)-permeable cation channels crucial for diverse cellular functions.
  • Dysregulation of TRPC channel function is linked to various diseases.
  • TRPC channel activity is modulated by protein interactions affecting their regulation, scaffolding, and trafficking.

Purpose of the Study:

  • To provide an overview of intracellular trafficking pathways for TRPC channels.
  • To discuss the mechanisms and components involved in the trafficking of TRPC1-TRPC7.
  • To highlight the importance of trafficking in regulating TRPC channel plasma membrane localization and function.

Main Methods:

  • Literature review of studies on TRPC channel trafficking.
  • Analysis of protein interactions influencing TRPC channel regulation and localization.
  • Examination of cellular mechanisms controlling TRPC channel surface expression.

Main Results:

  • Intracellular trafficking is a key mechanism controlling TRPC channel plasma membrane localization.
  • Numerous proteins interact with TRPC channels to regulate their trafficking and function.
  • Specific pathways and components involved in TRPC1-TRPC7 trafficking are increasingly understood.

Conclusions:

  • Understanding TRPC channel trafficking is essential for comprehending their role in cellular physiology and disease.
  • Targeting TRPC channel trafficking may offer therapeutic strategies for associated disorders.
  • Further research into the detailed mechanisms of TRPC channel trafficking will elucidate their complex regulation.
Keywords:
Ca(2+) signalingIntracellular traffickingMicrodomainsRegulationTRPC channels

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