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Updated: Apr 27, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
19.1K
[Genetics of primary headache syndromes]
1Abteilung Neurologie mit Schwerpunkt Epileptologie, Hertie-Institut für Klinische Hirnforschung, Universitätsklinikum Tübingen, Hoppe-Seyle-Str. 3, 72076, Tübingen, Deutschland, tobias.freilinger@uni-tuebingen.de.
Summary
Migraine genetics are complex, with hemiplegic migraine offering insights into rare monogenic forms. Recent advances in genome-wide association studies are illuminating the genetic underpinnings of common migraine types.
Area of Science:
- Neurogenetics
- Molecular Medicine
- Genomics
Context:
- Migraine is a prevalent neurological disorder with a significant genetic basis.
- Hemiplegic migraine (HM) serves as a prototypic monogenic form, with identified causative genes.
- Understanding genetic factors is crucial for elucidating migraine pathophysiology.
Purpose:
- To review the current understanding of migraine genetics.
- To highlight recent advancements in complex migraine genetics research.
- To provide insights into the genetic basis of primary headache disorders.
Summary:
- Monogenic forms of migraine, like HM, have provided foundational genetic insights.
- Genome-wide association studies (GWAS) are identifying risk variants for common migraine types.
- Preliminary genetic data for cluster headache and tension-type headache are also discussed.
Impact:
- Advances in understanding HM genetics inform broader migraine research.
- Identification of complex genetic risk factors paves the way for targeted therapies.
- This review consolidates current knowledge, guiding future research in headache genetics.
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