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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Cardiac magnetic resonance evaluation of left ventricular remodelling distribution in cardiac amyloidosis

Eduardo Pozo1, Anubhav Kanwar2, Rajiv Deochand3

  • 1The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, New York, USA Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, Madrid, Spain.

Heart (British Cardiac Society)
|July 12, 2014
PubMed

Insights

Cardiac amyloidosis (CA) often shows asymmetric left ventricular hypertrophy (LVH) and unusual remodeling patterns on cardiac magnetic resonance (CMR). Traditional criteria for CA have low sensitivity, highlighting the need for advanced imaging analysis.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiomyopathy Research

Background:

  • Cardiac amyloidosis (CA) presents with characteristic echocardiographic findings like concentric left ventricular hypertrophy (LVH).
  • Cardiac magnetic resonance (CMR) offers detailed anatomical visualization crucial for diagnosing cardiomyopathies.
  • Understanding CA's specific morphological features and remodeling patterns is essential for accurate diagnosis.

Purpose of the Study:

  • To characterize the morphological features and remodeling patterns of CA using CMR.
  • To determine the diagnostic accuracy of CMR for CA.
  • To evaluate the utility of traditional echocardiography and electrocardiography criteria for CA diagnosis.

Main Methods:

  • Retrospective analysis of patients referred for CMR due to suspected CA.
  • CA diagnosis confirmed by endomyocardial biopsy and/or characteristic late gadolinium enhancement patterns.
  • Assessment of left ventricular hypertrophy (LVH), relative wall thickness (RWT), and LV remodeling using cine sequences.

Main Results:

  • In 130 patients, 51 (39.2%) were diagnosed with CA.
  • CA patients exhibited increased LV wall thickness and LV mass index.
  • Asymmetric LVH was present in 68.6%, and atypical remodeling in 42% of CA patients.
  • A model combining RWT, asymmetric LVH, and LVMI achieved 88% diagnostic accuracy for CA.

Conclusions:

  • Asymmetric LVH and non-concentric remodeling are frequent in CA.
  • Increased LV mass index, RWT, and asymmetric LVH are key indicators for CA diagnosis.
  • Traditional diagnostic criteria for CA demonstrate limited sensitivity.
Abstract

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