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Genetic oscillations. A Doppler effect in embryonic pattern formation.

Daniele Soroldoni1, David J Jörg2, Luis G Morelli3

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. Medical Research Council (MRC)-National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.

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Summary
This summary is machine-generated.

The rhythm of embryonic segmentation is not solely controlled by genetic oscillations. Tissue shortening acts as a second time scale, influencing segmentation speed via a Doppler effect.

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Area of Science:

  • Developmental biology
  • Genetics
  • Biophysics

Background:

  • Embryonic development involves coordinated temporal and spatial cues for body axis segmentation.
  • The rhythm of segmentation in sequential segmenting animals is traditionally attributed to genetic oscillation timescales.

Purpose of the Study:

  • To investigate the factors controlling the temporal period of segmentation in zebrafish embryos.
  • To determine if genetic oscillation timescales alone explain segmentation rhythm.

Main Methods:

  • Real-time measurements of genetic oscillations in zebrafish embryos.
  • Analysis of tissue shortening rates and oscillation profile changes.

Main Results:

  • The timescale of genetic oscillations is insufficient to explain the segmentation period.
  • Tissue shortening contributes to the segmentation period via a Doppler effect.
  • Oscillation profile changes across the tissue modulate the Doppler effect.

Conclusions:

  • Segmentation rhythm is an emergent property.
  • It is controlled by the interplay of genetic oscillation timescales, oscillation profile changes, and tissue shortening.