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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Reduced information processing speed as primum movens for cognitive decline in MS.

Jeroen Van Schependom¹, Marie B D'hooghe², Krista Cleynhens³

¹Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel (VUB) Brussels/Faculté de Psychologie et des sciences de l'éducation, Place du Parc, 20 UMons, Mons, Belgium Jeroen.Van.Schependom@vub.ac.be.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|July 12, 2014

Summary

Information processing speed (IPS) declines fastest in multiple sclerosis (MS) patients, emerging as the earliest cognitive deficit. This impacts daily activities, with significant decline noted around age 56 on the SDMT.

Keywords:

NSBMS SDMT Survival analysis cognitive decline multiple sclerosis

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Area of Science:

Neurology
Neuropsychology
Clinical Neuroscience

Background:

Cognitive impairment affects 50% of multiple sclerosis (MS) patients, impacting daily life.
Most MS cognitive studies are cross-sectional or focus on early disease stages.

Purpose of the Study:

To determine the time course of cognitive domain decline in MS.
To identify the earliest affected cognitive domains in MS.

Main Methods:

Neuropsychological data from 514 MS patients were analyzed.
Kaplan-Meier survival curves and Cox-proportional hazard models were used.
Factors influencing cognitive decline time course were examined.

Main Results:

Information processing speed (IPS) tests showed significantly faster decline than other cognitive tests.
Median age for pathological decline was 56.2 years for SDMT and 63.9 years for a memory task (CLTR).

Conclusions:

IPS is the most affected cognitive domain in MS.
IPS deficits are the first to emerge in the course of MS.