Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate

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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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Chao Ma1, Chunxiao Liu1, Peng Huang2

  • 1Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China.

Oncology Letters
|July 12, 2014
PubMed

Insights

The study found that the GA genotype of the Axin2 gene SNP rs2240308 is associated with a reduced risk of prostate cancer, suggesting it may be a protective factor and a potential biomarker for early diagnosis.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • The Wnt signaling pathway is integral to human cancer development.
  • Axis inhibition protein 2 (Axin2) is a key scaffold protein in Wnt signaling, acting as a tumor suppressor.
  • Prostate cancer is a significant health concern, and understanding its genetic underpinnings is crucial.

Purpose of the Study:

  • To investigate the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 (G/A) and prostate cancer incidence.
  • To determine if specific genotypes of rs2240308 confer a risk or protective effect against prostate cancer.
  • To explore the potential of Axin2 SNP rs2240308 as a biomarker for prostate cancer predisposition and early detection.

Main Methods:

  • A case-control study involving 103 prostate cancer patients and 100 cancer-free male controls.
  • Genotyping of the Axin2 SNP rs2240308 (G/A) using genomic DNA extracted from peripheral blood samples.
  • Statistical analysis to calculate odds ratios and confidence intervals for different genotypes.

Main Results:

  • A higher incidence of prostate cancer was observed in subjects with the homozygous GG genotype.
  • The GA genotype of Axin2 SNP rs2240308 showed a significantly reduced cancer incidence (OR=0.377, P=0.001), indicating a protective effect.
  • The AA genotype did not show a significant association with prostate cancer risk (OR=0.830, P=0.712) compared to the GG genotype.

Conclusions:

  • The GA genotype of the Axin2 gene SNP rs2240308 exhibits a protective effect, significantly decreasing the risk of prostate cancer.
  • This finding suggests that variations in the Axin2 gene at this position may influence prostate cancer development.
  • The Axin2 SNP rs2240308 could serve as a valuable biomarker for prostate cancer predisposition and early diagnosis.
Keywords:
Axin2Wnt signaling pathwayprostate cancerrs2240308single nucleotide polymorphism

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