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Cytomegalovirus Infection following Kidney Transplantation: a Multicenter Study of 3065 Cases

B Einollahi1

  • 1Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

International Journal of Organ Transplantation Medicine
|July 12, 2014
PubMed
Abstract

Insights

Cytomegalovirus (CMV) infection is common after kidney transplants, especially within six months. Key risk factors include graft impairment and time post-transplant, highlighting the need for vigilant monitoring.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplant Immunology

Background:

  • Cytomegalovirus (CMV) infection is a significant post-transplant complication.
  • Kidney transplant recipients are particularly vulnerable to CMV disease.

Purpose of the Study:

  • To determine the incidence of CMV infection in kidney transplant recipients.
  • To identify risk factors associated with CMV infection in this population.

Main Methods:

  • A retrospective multicenter study involving 3065 kidney transplant recipients.
  • Routine monitoring using CMV-pp65 antigenemia assay, hematological, and biochemistry tests.
  • Data collected from April 2008 to January 2011 across 17 Iranian transplant centers.

Main Results:

  • The incidence of CMV infection was 21.9%, predominantly within the first six months post-transplant.
  • Significant risk factors included higher cyclosporine levels, lower hemoglobin, elevated ALT, increased fasting blood sugar, dyslipidemia, deceased donor recipients, and graft impairment.
  • Multivariate analysis identified time since transplantation and renal allograft failure as independent risk factors.

Conclusions:

  • CMV infection is a frequent complication in the early period after kidney transplantation.
  • Kidney graft impairment is a critical factor associated with CMV infection risk.
Keywords:
Cytomegalovirus infectionIncidenceKidney transplantationRisk factor

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