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Updated: Apr 27, 2026
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Laparoscopic Left Liver Sectoriectomy of Caroli's Disease Limited to Segment II and III
Published on: February 27, 2009
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Liver transplantation for caroli disease
M Zahmatkeshan1, A Bahador2, B Geramizade3
1Department of pediatrics, school of medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
International Journal of Organ Transplantation Medicine
|July 12, 2014
Summary
Caroli disease, a rare bile duct disorder, necessitates liver transplantation in severe cases. This study reviewed four transplant patients, finding good outcomes with one biliary complication.
Area of Science:
- Hepatology
- Gastroenterology
- Transplant Surgery
Background:
- Caroli disease is a rare congenital condition involving intrahepatic bile duct dilation.
- Severe cases with recurrent infections and portal hypertension may require liver transplantation.
Observation:
- Four patients with Caroli disease underwent liver transplantation at Shiraz University of Medical Science.
- Patients presented with liver failure, recurrent cholangitis, and portal hypertension unresponsive to treatment.
Findings:
- The mean patient age was 24.5 years (range 18-36), with three females and one male.
- The mean MELD score was 17.5 (range 11-23).
- All patients experienced a favorable post-transplant course, except for one who required biliary reconstruction for post-operative stricture.
Implications:
- Liver transplantation is a viable treatment for end-stage Caroli disease.
- Careful post-transplant management is crucial, particularly for biliary complications.
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