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Updated: Apr 27, 2026

Evaluation of Extracellular Vesicle Function During Malaria Infection
Published on: February 14, 2018
Malaria and vascular endothelium
Aristóteles Comte de Alencar Filho1, Marcus Vinícius Guimarães de Lacerda2, Katashi Okoshi3
1Universidade Federal do Amazonas, Manaus, AM, Brazil.
Abstract:
Involvement of the cardiovascular system in patients with infectious and parasitic diseases can result from both intrinsic mechanisms of the disease and drug intervention. Malaria is an example, considering that the endothelial injury by Plasmodium-infected erythrocytes can cause circulatory disorders. This is a literature review aimed at discussing the relationship between malaria and endothelial impairment, especially its effects on the cardiovascular system. We discuss the implications of endothelial aggression and the interdisciplinarity that should guide the malaria patient care, whose acute infection can contribute to precipitate or aggravate a preexisting heart disease.
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