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Related Experiment Videos

[Hepatitis B vaccination in alcoholics].

N Maruyama, M Sata, K Ishii

    Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
    |January 1, 1989
    PubMed
    Summary

    Hepatitis B (HB) vaccination shows a poor response in alcoholics, with only 53.3% developing antibodies. Impaired cellular immunity may be the cause, suggesting re-vaccination may be necessary for non-responders.

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    The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.

    British journal of pharmacology·2013

    Area of Science:

    • Immunology
    • Hepatology

    Context:

    • Alcoholism is a significant public health issue with known impacts on immune function.
    • Hepatitis B vaccination is crucial for preventing liver disease, especially in at-risk populations like alcoholics.

    Purpose:

    • To investigate the immune response to Hepatitis B (HB) vaccination in individuals with alcoholism.
    • To explore potential immunological factors contributing to vaccination non-response in this cohort.

    Summary:

    • Fifteen alcoholics received a 20 microgram HB vaccination regimen (3 doses).
    • Only 8 (53.3%) developed detectable anti-HBs antibodies, with low titers in responders.
    • Non-responders exhibited lower peripheral lymphocyte counts and/or OKT4/OKT8 ratios compared to a control.
    • No significant differences were observed in anti-HAV, anti-EBNA, immunoglobulin levels, or lymphocyte blastogenesis between responders and non-responders.

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    Impact:

    • Suggests impaired cellular immunity contributes to poor HB vaccine response in alcoholics.
    • Highlights the potential need for re-vaccination strategies in alcoholic patients who do not respond adequately to initial HB vaccination.
    • Informs clinical practice regarding hepatitis B prevention in vulnerable populations.