Polymeric supra-amphiphiles based on terminal group electrostatic interactions: fabrication of micelles with
1Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P.R. China.
Langmuir : the ACS Journal of Surfaces and Colloids
|July 12, 2014
Abstract:
On the basis of terminal group electrostatic interactions (TGEI), a supra-amphiphile is formed between a homopolymer of polylactic acid with carboxyl group at one end (PLA-COOH) and hepta-6-hydrazyl-β-cyclodextrin (HH-CD). The amphiphile can self-assemble into a micellar structure in aqueous solution. The outer surface of the micelle, which is composed of cyclodextrins, can be further modified via host-guest interactions. Considering the biocompatibility of the building blocks, the application of the micelles in a nanocarrier of anticancer drugs is further explored.
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