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A Method of Permeabilization of Drosophila Embryos for Assays of Small Molecule Activity

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Published on: July 13, 2014

Mercury, APOE, and child behavior.

Sharon Ng¹, Ching-Chun Lin¹, Suh-Fang Jeng²

¹Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.

|July 12, 2014

Summary

This summary is machine-generated.

Methylmercury (MeHg) exposure may affect child behavior, particularly in individuals with the Apolipoprotein E (APOE) epsilon 4 allele. APOE ε4 carriers with higher cord blood mercury levels showed increased behavioral issues at age two.

Keywords:

Apolipoprotein E (APOE)Child Behavior Checklists/1.5-5 (CBCL/1.5-5)Child behavior Genetic susceptibility Methylmercury (MeHg)

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An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

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Published on: October 4, 2018

Area of Science:

Environmental Health
Neuroscience
Genetics

Background:

Methylmercury (MeHg) is a known neurotoxicant with potential adverse effects on child behavior.
Inconsistencies in MeHg's impact suggest modulating factors, possibly including genetic variations.
The specific role of Apolipoprotein E (APOE) variants, particularly the epsilon 4 (ε4) allele, in MeHg neurotoxicity remains unclear.

Purpose of the Study:

To investigate the influence of APOE variants on the relationship between cord blood mercury (Hg) levels and child behavior.
To determine if APOE genotype modifies the neurotoxic effects of MeHg exposure in early childhood.

Main Methods:

Recruited 166 mother-infant pairs at delivery for cord blood collection.
Analyzed cord blood for mercury (Hg) concentration and APOE genotype.
Assessed child behavior at age two using the Child Behavior Checklist (CBCL).

Main Results:

Increased cord blood Hg concentrations were consistently associated with higher CBCL syndrome scores in APOE ε4 carriers.
Elevated cord blood Hg in APOE ε4 carriers correlated with significantly higher scores in internalizing, emotionally reactive, and anxiety/depression categories.
Borderline significant increases in general externalizing and aggressive syndromes were observed in APOE ε4 carriers with higher Hg levels.

Conclusions:

APOE genotype appears to modify the neurotoxic effects of MeHg on child behavior.
APOE ε4 carriers may exhibit increased vulnerability to the behavioral impacts of MeHg exposure during early development.