Related Experiment Video
Updated: Apr 27, 2026

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells
Published on: November 7, 2025
GPCRserver: an accurate and novel G protein-coupled receptor predictor
Renxiang Yan1, Xiaofeng Wang, Lanqing Huang
1Institute of Applied Genomics, School of Biological Sciences and Engineering, Fuzhou University, Fuzhou 350002, China. yanrenxiang@fzu.edu.cn.
Abstract:
G protein coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, pass through the cellular membrane seven times and play diverse biological roles in the cells such as signaling, transporting of molecules and cell-cell communication. In this work, we develop a web server, namely the GPCRserver, which is capable of identifying GPCRs from genomic sequences, and locating their transmembrane regions. The GPCRserver contains three modules: (1) the Trans-GPCR for the transmembrane region prediction by using sequence evolutionary profiles with the assistance of neural network training, (2) the SSEA-GPCR for identifying GPCRs from genomic data by using secondary structure element alignment, and (3) the PPA-GPCR for identifying GPCRs by using profile-to-profile alignment. Our predictor was strictly benchmarked and showed its favorable performance in the real application. The web server and stand-alone programs are publicly available at .
More Related Videos
Related Concept Videos
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors
G-protein Coupled Receptors
G-protein Coupled Receptors
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical,...
Activation and Inactivation of G Proteins

