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Pyrazine-derived disulfide-reducing agent for chemical biology

John C Lukesh1, Kelly K Wallin, Ronald T Raines

  • 1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1322, USA. rtraines@wisc.edu.

Chemical Communications (Cambridge, England)
|July 12, 2014
PubMed
Summary

A new disulfide-reducing agent, 2,3-bis(mercaptomethyl)pyrazine (BMMP), offers superior reactivity compared to the long-standing standard, dithiothreitol (DTT). This discovery provides a more effective tool for biochemical research and applications.

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