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Related Experiment Video

Updated: Apr 27, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

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Optimizing the skeletal muscle biopsy.

Karen M Weidenheim1

  • 1Departments of Pathology, Neurology and Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Room 204, 10469, Bronx, NY, USA, kweidenh@montefiore.org.

Methods in Molecular Biology (Clifton, N.J.)
|July 13, 2014
PubMed
Summary

Pathologists need skeletal muscle biopsy knowledge for diagnosing rare genetic and drug-induced myopathies. This expertise is crucial for accurate analysis, especially in complex patient cases.

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Area of Science:

  • Pathology
  • Neuromuscular Disorders
  • Skeletal Muscle Biology

Background:

  • Genetic testing aids common muscular dystrophies but less common myopathies require pathological analysis.
  • Pathologists encounter diverse cases including familial neuromuscular disorders, autoimmune conditions, and drug-induced myopathies.
  • Complex patient comorbidities can complicate clinical and pathological assessments of muscle disorders.

Purpose of the Study:

  • To emphasize the continued importance of pathological analysis in diagnosing skeletal muscle disorders.
  • To highlight the diagnostic utility and limitations of skeletal muscle biopsy for practicing pathologists.
  • To guide pathologists in managing and analyzing muscle biopsy specimens.

Main Methods:

  • Review of diagnostic challenges in skeletal myopathies.

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Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy
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  • Discussion of the role of pathological examination in identifying various myopathies.
  • Consideration of the practical aspects of skeletal muscle biopsy processing.

    • Main Results:

    • Skeletal muscle biopsy remains essential for diagnosing less common genetic, congenital, and toxic myopathies.
    • Pathological analysis is critical when genetic testing is inconclusive or not applicable.
    • Drug-induced myopathies, such as those from statins, necessitate careful pathological evaluation.

    Conclusions:

    • A strong understanding of skeletal muscle pathology is vital for contemporary pathologists.
    • Pathologists must be adept at interpreting muscle biopsies, particularly in complex cases.
    • Decisions regarding in-house versus reference laboratory analysis of biopsies are critical.