Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Vaccinations01:51

Vaccinations

43.9K
Overview
43.9K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

62
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
62
Development of Human Microbiota01:30

Development of Human Microbiota

60
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
60
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

570
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
570
Vaccines01:21

Vaccines

86
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
86

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

National Survival Rates among 22-Week Live Births in the United States: Associations with Active Treatment.

American journal of perinatology·2026
Same author

Improving 1-year survival at 22 weeks gestation: which perinatal interventions matter?

American journal of obstetrics & gynecology MFM·2026
Same author

Evaluating TikTok Content on Gestational Diabetes Screening: Accuracy and Impact.

American journal of perinatology·2026
Same author

Studying the effects of McRoberts and neonate-focused maneuvers on the neonatal brachial plexus during shoulder dystocia.

Frontiers in bioengineering and biotechnology·2025
Same author

Efficacy, Immunogenicity, and Safety of an Investigational Maternal Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

The current state of pertussis vaccination in pregnancy around the world, with recommendations for improved care: Consensus statements from the Global Pertussis Initiative.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2024

Related Experiment Video

Updated: Apr 27, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.3K

Maternal vaccination: moving the science forward.

Azure N Faucette1, Benjamin L Unger1, Bernard Gonik2

  • 1Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA.

Human Reproduction Update
|July 13, 2014
PubMed
Summary
This summary is machine-generated.

Maternal vaccination offers protection against infections for mothers and newborns. Further research is needed to understand vaccine efficacy, safety, and improve public acceptance for better maternal and infant health outcomes.

Keywords:
animal modelantibodyimmunologypregnancyvaccine

More Related Videos

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

2.1K

Related Experiment Videos

Last Updated: Apr 27, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.3K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

2.1K

Area of Science:

  • Immunology
  • Public Health
  • Obstetrics

Background:

  • Infections pose significant risks to pregnant women and newborns.
  • Vaccine-preventable infections contribute substantially to maternal and neonatal morbidity.
  • Maternal vaccination is a key strategy to combat these infections.

Purpose of the Study:

  • To review the current status and identify knowledge gaps in maternal vaccination.
  • To formulate future research directions for maternal vaccines.
  • To address challenges in maternal vaccine development and acceptance.

Main Methods:

  • A systematic literature search was conducted using PubMed.
  • Articles were selected based on relevance and quality.
  • An outline of current knowledge and research gaps guided the review.

Main Results:

  • Maternal vaccines induce immune protection in mothers and neonates.
  • Pregnancy-associated immune modulation affects vaccine response.
  • Gaps in knowledge regarding efficacy, safety, and public acceptance persist.

Conclusions:

  • Interdisciplinary collaboration is crucial for understanding immune responses to maternal vaccines.
  • Integrating animal models with human studies is essential for vaccine evaluation.
  • Systems biology approaches can enhance the speed, accuracy, and safety of maternal vaccine development.