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Colonic cribriform carcinoma, a morphologic pattern associated with low survival
Leonardo Saul Lino-Silva1, Rosa Angelica Salcedo-Hernández2, Angel Herrera-Gómez2
1Instituto Nacional de Cancerología, Mexico City, Mexico saul.lino.sil@gmail.com.
International Journal of Surgical Pathology
|July 13, 2014
Summary
Cribriform colonic carcinoma (CCC) is an underrecognized aggressive variant of colorectal cancer. This study shows CCC is linked to significantly lower survival rates and advanced disease compared to conventional adenocarcinoma.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Colorectal carcinoma is a prevalent and heterogeneous cancer.
- Morphological patterns can indicate prognosis, with specific variants linked to adverse outcomes.
- Cribriform colonic carcinoma (CCC) is a recognized histological variant associated with poor prognosis.
Purpose of the Study:
- To compare the prognosis and survival of cribriform colonic carcinoma (CCC) versus conventional colon adenocarcinomas.
- To investigate the clinicopathological features of CCC.
- To highlight the prognostic significance of recognizing CCC.
Main Methods:
- Retrospective analysis of 18 cases of CCC.
- Comparison with 228 cases of conventional colon adenocarcinomas.
- Evaluation of clinicopathological features including stage, lymph node status, lymphovascular invasion, and overall survival.
Main Results:
- CCC constituted 7.3% of adenocarcinomas in this series, presenting at advanced stages (III/IV).
- CCC cases showed high rates of subserosal invasion (>90%), lymph node metastasis (>5 nodes, 90%), and lymphovascular invasion (89%).
- Five-year survival for CCC was significantly lower (56.8%) than for conventional adenocarcinoma (83.3%, P = .035), even when staged similarly.
Conclusions:
- Cribriform colonic carcinoma is an underrecognized entity associated with aggressive disease characteristics.
- CCC demonstrates significantly worse survival outcomes compared to conventional intestinal-type adenocarcinoma.
- Accurate recognition of CCC is crucial for accurate staging, prognosis, and potentially guiding treatment strategies.
