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Related Concept Videos

Cholecystitis01:20

Cholecystitis

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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis I: Introduction01:25

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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Chronic Pancreatitis II: Pathophysiology01:21

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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Appendicitis01:19

Appendicitis

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Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: Apr 27, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
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Sporadic lymphoplasmacytic cholecystitis: a clinicopathologic entity.

Suntrea T G Hammer1, Henry D Appelman2

  • 1From the University of Michigan Health System, Ann Arbor, MI. Suntrea.Hammer@utsouthwestern.edu.

American Journal of Clinical Pathology
|July 13, 2014
PubMed
Summary

Sporadic lymphoplasmacytic cholecystitis (LPC) occurs in older men, often with gallstones, and presents like acute cholecystitis. This finding expands the understanding of LPC beyond chronic biliary tract disease.

Keywords:
Chronic cholecystitisLymphoplasmacytic cholecystitis

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Area of Science:

  • Gastroenterology
  • Pathology
  • Hepatobiliary Surgery

Background:

  • Lymphoplasmacytic cholecystitis (LPC) is typically associated with chronic biliary tract disease.
  • The sporadic form of LPC has not been well-characterized.

Purpose of the Study:

  • To describe the clinicopathologic features of sporadic lymphoplasmacytic cholecystitis.
  • To differentiate sporadic LPC from LPC associated with pancreatobiliary disease.

Main Methods:

  • Retrospective review of cholecystectomies over one year.
  • Analysis of histologic, radiologic, and clinical findings.
  • Comparison of sporadic LPC cases with noninflamed controls and obstructive LPC cases.

Main Results:

  • Sporadic LPC constituted 7% of cholecystectomies, with a male predominance (54.2%).
  • Patients often presented with acute inflammation signs; gallstones were present in 71.4%.
  • No unique histologic features distinguished sporadic LPC from obstructive LPC.

Conclusions:

  • Lymphoplasmacytic cholecystitis can occur sporadically, with or without gallstones, and outside traditional disease categories.
  • Sporadic LPC affects a distinct demographic (older men) and can mimic acute cholecystitis clinically.