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Multiple macroenzymes in a patient with AIDS: diagnosis using ultrafiltration
Sara P Wyness1, Michael A Yee2, Sonia L La'ulu1
1From the ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT;
American Journal of Clinical Pathology
|July 13, 2014
Summary
This study reports multiple immunoglobulin-bound enzymes (macroenzymes) in an AIDS patient. Ultrafiltration (UF) proved more reliable than polyethylene glycol (PEG) precipitation for detecting macroenzymes in cases of hypergammaglobulinemia.
Area of Science:
- Clinical Biochemistry
- Immunology
- Virology
Background:
- Elevated enzyme concentrations (creatine kinase, amylase, liver enzymes) were observed in an asymptomatic individual with a history of Acquired Immunodeficiency Syndrome (AIDS).
- Hypergammaglobulinemia was a notable characteristic of the patient's condition.

