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Updated: Apr 27, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Heterotopic ossification: a systematic review.

Dafydd S Edwards¹, J C Clasper²

¹Centre for Blast Injury Studies, Imperial College London, London, UK.

Journal of the Royal Army Medical Corps

|July 13, 2014

Summary

This summary is machine-generated.

Heterotopic ossification (HO), bone formation in soft tissues, is a significant issue for military personnel, especially after blast amputations. Current prevention methods are limited, highlighting a need for further research into its causes and treatments.

Keywords:

PLASTIC & RECONSTRUCTIVE SURGERY REHABILITATION MEDICINE

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Area of Science:

Orthopedics
Regenerative Medicine
Military Medicine

Background:

Heterotopic ossification (HO) is extraskeletal bone formation, historically noted in fractures and military wounds.
HO is prevalent after joint replacement, trauma, and in military casualties with blast-related amputations.
Risk factors include blast injury, amputation severity, and associated brain injuries.

Purpose of the Study:

To review the military problem of heterotopic ossification.
To identify current research concepts and experimental theories regarding HO.
To conduct a gap analysis of existing knowledge, particularly concerning military aspects.

Main Methods:

Systematic review of research articles.
Searches conducted in PubMed and Cochrane Database.
Inclusion of articles referencing HO, with a focus on military relevance.

Main Results:

Identified 637 relevant articles out of 7891 initially found.
Highlighted the increased incidence of HO in military casualties from blast-related amputations.
Confirmed limitations in understanding the exact cellular events and prevention strategies for HO.

Conclusions:

HO presents significant challenges in military rehabilitation and prosthetic use.
Current prevention strategies like anti-inflammatory medication and radiation have limitations, especially in complex military casualties.
Further research is needed to identify the cellular mechanisms of HO and develop effective preventative and therapeutic interventions for military personnel.